Dermal and Transdermal Drug Delivery PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Dermal and Transdermal Drug Delivery PDF full book. Access full book title Dermal and Transdermal Drug Delivery by Robert Gurny. Download full books in PDF and EPUB format.

Dermal and Transdermal Drug Delivery

Dermal and Transdermal Drug Delivery PDF Author: Robert Gurny
Publisher:
ISBN:
Category :
Languages : en
Pages :

Book Description

Dermal and Transdermal Drug Delivery

Dermal and Transdermal Drug Delivery PDF Author: Robert Gurny
Publisher:
ISBN:
Category :
Languages : en
Pages :

Book Description


Topical and Transdermal Drug Delivery

Topical and Transdermal Drug Delivery PDF Author: Heather A. E. Benson
Publisher: John Wiley & Sons
ISBN: 1118140494
Category : Medical
Languages : en
Pages : 432

Book Description
Practical drug development approaches presented by leadingexperts Designed to support the development of new, effectivetherapeutics, Topical and Transdermal Drug Delivery: Principlesand Practice explains the principles underlying the field andthen demonstrates how these principles are put into practice in thedesign and development of new drug products. Drawing together andreviewing the latest research findings, the book focuses onpractical, tested, and proven approaches that are backed byindustry case studies and the authors' firsthand experience.Moreover, the book emphasizes the mechanistic information that isessential for successful drug product development. Topical and Transdermal Drug Delivery: Principles andPractice is divided into two parts: Part One, Current Science, Skin Permeation, andEnhancement Approaches, offers readers a fundamental understandingof the underlying science in the field. It describes the principlesand techniques needed to successfully perform experimentalapproaches, covering such issues as skin permeation, enhancement,and assessment. Part Two, Topical and Transdermal Product Development,guides readers through the complete product development processfrom concept to approval, offering practical tips and cautions fromexperts in the field. This part also discusses regulations that arespecific to the development of dermal drug products. The finalchapter explores current and future trends, forecasting newdevelopment techniques and therapeutics. Throughout the book, the authors clearly set forth the basicscience and experimental procedures, making it possible forresearchers to design their own experimental approaches andaccurately interpret their results. With contributions from experienced drug researchers, this textis highly recommended for all researchers involved in topical andtransdermal product development who need to know both the state ofthe science and the standards of practice.

Dermal Drug Delivery

Dermal Drug Delivery PDF Author: Tapash K. Ghosh
Publisher: CRC Press
ISBN: 1315356643
Category : Medical
Languages : en
Pages : 447

Book Description
With the continued advancement of better-quality control and patient outcome reporting systems, changes in the development, control, and regulation of all pharmaceutical delivery systems including transdermal and topical products have been happening on a continuous basis. In light of various quality issues that have been reported by patients and practitioners resulting in the recall or removal of products from the market, both the pharmaceutical industries and regulatory agencies have been adopting new measures to address these issues. With chapters written by experts in this field, this book takes a 21st century multidisciplinary and cross-functional look at these dosage forms to improve the development, design, manufacturing, quality, clinical performance, safety, and regulation of these products. This book offers a wealth of up-to-date information organized in a logical sequence corresponding to various stages of research, development, and commercialization of dermal drug delivery products. The authors have been carefully selected from different sectors of pharmaceutical science for their expertise in their selected areas to present objectively a balanced view of the current state of these products development and commercialization via regulatory approval. Their insights will provide useful information to others to ensure the successful development of the next generation dermal drug products. Key Features: Presents current advancements including new technologies of transdermal and topical dosage forms. Presents challenges in the development of the new generation of transdermal and topical dosage forms. Introduces new technologies and QbD (quality by design) aspects of manufacturing and control strategies. Includes new perspectives on pre-clinical and clinical development, regulatory considerations, safety and quality. Discusses regulatory challenges, gaps, and future considerations for dermal drug delivery systems.

Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems PDF Author: Jonathan Hadgraft
Publisher: CRC Press
ISBN: 0203909682
Category : Medical
Languages : en
Pages : 328

Book Description
Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery PDF Author: Ryan F. Donnelly
Publisher: John Wiley & Sons
ISBN: 1118734513
Category : Science
Languages : en
Pages : 296

Book Description
This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

Nanoparticles for Dermal and Transdermal Drug Delivery

Nanoparticles for Dermal and Transdermal Drug Delivery PDF Author: Okoro Uchechi
Publisher:
ISBN:
Category : Science
Languages : en
Pages :

Book Description
Nanoparticles for Dermal and Transdermal Drug Delivery.

The Art and Science of Dermal Formulation Development

The Art and Science of Dermal Formulation Development PDF Author: Marc B. Brown
Publisher: CRC Press
ISBN: 0429596065
Category : Medical
Languages : en
Pages : 248

Book Description
The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes. Key Features: Presents a practical guide for both industry and academia Focuses on and draws together the fundamental principles behind transdermal and topical drug delivery Illustrates the practicalities of formulation design using key case studies Gives an understanding of the skin as a route of delivery and how formulation development for such application differs from that for other administration routes

Transdermal Drug Delivery

Transdermal Drug Delivery PDF Author: Jonathan Hadgraft
Publisher: Marcel Dekker Incorporated
ISBN:
Category : Medical
Languages : en
Pages : 324

Book Description


Transdermal and Intradermal Delivery of Therapeutic Agents

Transdermal and Intradermal Delivery of Therapeutic Agents PDF Author: Ajay K Banga
Publisher: CRC Press
ISBN: 1439805105
Category : Medical
Languages : en
Pages : 309

Book Description
Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology. A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers: Commercial development of devices and products based on transdermal physical enhancement technologies Selecting optimal enhancement technology for a specific drug molecule using case studies Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines Practical information on experimental procedures and challenges related to skin irritation and safety issues Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.

Investigation of Microemulsions and Their Microstructures for Transdermal and Dermal Drug Delivery

Investigation of Microemulsions and Their Microstructures for Transdermal and Dermal Drug Delivery PDF Author: Ji Zhang
Publisher:
ISBN:
Category : Drug delivery systems
Languages : en
Pages : 138

Book Description
Drug delivery through the skin, transdermally and topically, offers many advantages including reduced systemic toxicity and side-effects, avoidance of the hepatic first pass metabolism, improved patient compliance, enabling sustained or controlled drug release, and enhanced delivery to local target tissues. However, there are many challenges for this route of administration, the major one is the skin barrier function to drug permeation. Many different approaches have been studied and used for enhancing the drug skin permeation. Among them, chemical permeation enhancers and microemulsion formulations are some of widely studied approaches. The thesis work focused on microemulsion (ME) formulations for enhancing transdermal or dermal drug delivery. Specifically, the ME microstructures were investigated and correlated with enhancement effects of drug skin permeation or skin deposition. The results showed that a critical factor influencing ME formulation behavior was the water content that also correlated to the formulation microstructure, and the drug skin permeation increased significantly corresponding to the microstructure change from W/O, to Bi-continuous, and to O/W. This was the first time that this phenomenon had been systematically studied and reported, the microstructure of a microemulsion affected both hydrophobic and hydrophilic model drugs' transdermal permeation. The extent of trandermal permeation enhancement effect was more significant for hydrophobic drugs than hydrophilic drugs as water content increased and the corresponding microstructure changed in the ME formulation. Furthermore, at fixed water content, increasing oil content would result in higher transdermal permeation enhancement. The model drugs used in the study were lidocaine, ketoprofen, and caffeine, which represented compounds of varied physical and chemical properties. The findings were of practical significance for microemulsion formulation design and development in transdermal drug delivery. Secondly, in the present study, a combination of analytical methodologies was utilized to examine microemulsion microstructures. It was found that the cooling thermogram generated by Differential Scanning Calorimetry (DSC) provided a simple approach for microstructure determination, which to the author's knowledge, had not been reported before. Extensive DSC cooling experiments had been conducted to analyze three ME systems that had their microstructure characterized and known in the literature. It was showed that DSC derived microstructure results were in complete concordance with literature reports, and thus demonstrated that the cooling DSC method was an effective analytical technique for ME microstructure assessment. The results also showed that the DSC method provided additional advantages over conventional methods for being sensitive, accurate, and versatile. The developed cooling DSC methodology for ME microstructure analysis would greatly facilitate ME formulation characterization and development in the future. Finally, dermal delivery of hydrophobic drugs by microemulsion (ME) formulations and effect from ME microstructures were studied. The antifungal drug, clotrimazole (CLOT), was used as the model compound. ME formulations of different microstructures were prepared along water dilution line at fixed oil/(surfactant and co-surfactant) ratio of 1/9 (w/w) using isopropyl myristate as oil, Labrasol and Cremophor EL as surfactant and co-surfactant, and water. Permeation experiments on human cadaver skin were conducted for ME and the control formulations of different CLOT loads. Dermal delivery of CLOT assessed by the dermal drug concentrations was found to be significantly higher for MEs when compared with the control formulation, and the highest concentration was observed with O/W ME, suggesting ME microstructure was an important formulation variable for enhancing dermal delivery. ME gel formulations prepared by incorporating 1.0% (w/w) of Carbopol 980 showed comparable dermal CLOT concentration to MEs but up to 2.4 fold higher than the commercial CLOT cream product, Lotrimin®. Furthermore, FITC used as a model compound for highly hydrophobic drugs, was also studied for its dermal delivery by MEs in porcine skin penetration experiments. Results showed a consistent ME microstructure effect, suggested by significantly higher FITC concentrations in all skin layers, stratum corneum, viable epidermis, and dermis, from O/W ME over Bi-continuous and W/O MEs. Results from the present study highlighted ME microstructure effect on ME dermal delivery of hydrophobic drugs, and provided insight to drug dermal retention and transdermal permeation enhancements and their interplay.